Endothelin-1
| Net effect: | vasoconstriction, mostly |
|---|---|
| Secreted from | endothelium |
| Stimulus | Hypoxia Vessel wall injury angiotensin II, ADH, noradrenaline Raised in: CKD, AKI... |
| Inhibition | |
| Site of action | vasoconstrictive (via stimulation of ETA receptors on vascular smooth muscle) vasodilatory (via stimulation of ETB receptors on vascular endothelium) |
| Action | vasodilatation in renal medulla, vasoconstriction in renal cortex → renal vasoconstriction = ↓ GFR |