Endogenous regulation of vascular tone
Most vasoconstrictors bind to G protein → ↑ intracellular Ca2+ → smooth muscle contraction (by graded depolarisation)
- Angiotensin II
- Endothelin (see Renal circulation and cortex 1 in particular)
- Noradrenaline
| Vasoconstricting Agents | Vasodilating Agents |
|---|---|
| Endothelin-1 | Nitric oxide |
| Thromboxane A2 | Prostacyclin/prostaglandins |
| Angiotensin II | Beta-agonists |
| Noradrenaline (alpha 1-receptors) | Calcium-channel blockers |
| Bradykinin |
Endothelin
Stimulus: hypoxia, ATII, ADH, noradrenaline