Bradykinin
Activated kallikrein (e.g. from saliva) acts on alpha-2 globulin in plasma → release kallin → converted by tissue enzymes to bradykinin
Carcinoid tumours may secrete this!
| Net effect: | vasodilation |
|---|---|
| Secreted from | endothelium |
| Stimulus | enzymes contained in sweat |
| Inhibition | metabolised and removed in pulmonary circulation |
| Site of action | Endothelial cells |
| Action (function) | Vasodilation via nitric oxide ↑ capillary permeability ↑ GFR |
- Inactived by ACE inhibitors
- Icatibant blocks bradykinin-2 receptor (used for treatment of hereditary angioedema)