Renin
| Net effect | raises MAP |
|---|---|
| Secreted from | juxtaglomerular cells (in afferent arterioles) in kidneys |
| Stimulus | - ↓ renal perfusion (i.e. GFR, MAP, ECF) → ↑ sympathetic stimulation - hyponatraemia - loss of wall pressure in the afferent glomerular arteriole - ↓ NaCl concentration as detected by macula densa |
| Inhibition | inhibited by angiotensin II |
| Site of action | Angiotensinogen → angiotensin I (converted to active form in lungs) → angiotensin II |
| Action | Stimulates secretion of Aldosterone → net ↑ MAP |