reserves last 5 years
only found in animal products
cofactor for the conversion of homocysteine into methionine
cofactor for the isomerization of methylmalonyl CoA to Succinyl Co A

absorption

ingested form - bound to R protein
separated from R protein in duodenum by pancreatic proteases
binds to intrinsic factor (secreted by gastric parietal cells)
B12-IF complex binds to receptors in terminal ileum → uptake by endocytosis
processed by liver

deficiency

clinical presentation

neuropathy

#gastrointestinal