Protein C and S
- lives on endothelium - Endothelial function
- vit K-dependent
protein C
positive feedback:
- protein S
- activated by thrombin
effect:
- activated protein C = protease that inactivates cofactors Va, VIIIa (i.e. part of intrinsic pathway)
- i.e. part of normal inhibition mechanism of intrinsic pathway
- t½ 6h = 1st to be inactivated when there is no Vit K
protein S
is a cofactor of protein C. That's it.