Erythropoietin
| Net effect: | ↑ Hb |
|---|---|
| Secreted from | 90% kidneys 10% liver |
| Stimulus | tissue hypoxia → ↑ HIF-1 → ↑ expression of EPO gene minor: - noradrenaline, prostaglandins |
| Inhibition | |
| Acts on (action) | proliferation and differentiation of red cell precursors. |