Coagulation cascade
YOU THOUGHT YOU WERE DONE WITH THIS???
"detailed knowledge is not required" but it sure helps to contextualise everything else, so here goes.
intrinsic pathway (not so important)
Extrinsic pathway (very important)
Final common pathway
Regulation via negative feedback pathways
- See natural anticoagulants and fibrinolysis
- tl;dr
- Thrombin activates plasminogen to plasmin + stimulates production of antithrombin
- plasmin breaks down fibrin mesh
- Protein C and S inactivate Factor V and VIII
- Thrombin activates plasminogen to plasmin + stimulates production of antithrombin
related topics
natural anticoagulants and fibrinolysis
differences between unfractionated heparin and LMWH and Heparin
Coagulopathy in liver disease