gastric acid production

  • H+ secreted into stomach lumen by H+/K+ ATPase = "proton pump" on parietal cells
    • Cl secreted along with H+ via luminal Cl channels
  • about 2L produced per day

what's all that acid for

  • pepsinogen → pepsin which breaks down polypeptides in the stomach

stimulation

  • gastrin

inhibition

  • Secretin
  • VIP