endocrine pancreas

  • Normal value of blood glucose

Functional anatomy of the endocrine pancreas

  • Beta cells as insulin production units; alpha cells as glucagon production units
  • Stimulants to production
  • Proinsulin and C-peptide as necessary precursors in insulin manufacture
  • The insulin receptor and intracellular signalling paths as vital links in the effector chain
  • Effects of insulin upon glycogen, glycolysis, lipolysis and protein synthesis

Glucagon physiology

  • Stimulants to production
  • Effects of glucagon upon hepatic handling of glycogen, glucose, urea, fat and ketones
  • Physiological basis of insulin- and non-insulin- dependent diabetes mellitus
  • Clinical effects of untreated diabetes

Islets of Langerhans cell types

Cell type Hormone produced
Alpha cells Glucagon
Beta insulin
Delta somatostatin
Gamma polypeptides
Epsilon ghrelin

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