Effect of digoxin on cardiac AP

🌸 Digoxin inhibits Na/K ATPase

  • slows conduction through AV node
  • ↑ intracellular Na ⇒ ↓ Na-dependent Ca transport out of myocyte ⇒ ↑ intracellular Ca ⇒ ↑ inotropy

https://derangedphysiology.com/main/cicm-primary-exam/required-reading/cardiovascular-system/Chapter%20010/normal-processes-cardiac-excitation-and-electrical-activity
CV Physiology | Action Potentials
Calcium, Digoxin Toxicity and ‘Stone Heart’ Theory

#cardiac-physiology