Valproate
| Uses: | tonic-clonic seizures, primary generalised epilepsy |
|---|---|
| Mechanism of action | use-dependent block of Na channels |
| Dose | |
| Pharmacokinetics | Absorption Distribution Metabolism glucuronidation Elimination t 1/2 8-20h |
| Time course of action | |
| Adverse effects | |
| Contraindications | acute liver disease, acute porphyrias, mitochondrial disorders |