Tricyclic antidepressants
| Uses: | depression (as the name suggests), chronic pain... |
|---|---|
| Mechanism of action | inhibits reuptake of noradrenaline and 5HT → antidepressant effect Na channel blocker → analgesic effect |
| Pharmacokinetics | Absorption p450 Distribution plasma t½ 12-24h Metabolism Elimination |
| Adverse effects | anticholinergic effects, alpha antagonist effects = postural hypotension |
#pharmacology
that one anaesthetist who made a thing about this: see below
