Thiazides
Bendroflumethiazide as a type example
| Uses: | hypertension; oedema |
|---|---|
| Mechanism of action | inhibition of Na/Cl co-transporter in distal convoluted tubule → ↑ Na in distal tubule → ↑ Na exchange with K and H+ |
| Dose | 2.5mg OD |
| Pharmacokinetics | Absorption Distribution Metabolism Elimination 30% excreted unchanged in urine |
| Time course of action | onset 2h peak effect 3-6h duration of diuretic action 18-24h |
| Adverse effects | ↓ K, gout (from ↑ urate) |
| Contraindications | Addison's Hypercalcaemia Refractory hypokalaemia Hyponatraemia |