suxamethonium
decided to give it a page all on its own.
the favourite of traditional anaesthetists because it's fast acting
| Uses: | the old problematic fav RSI and laryngospasm - anywhere you want rapid paralysis |
|---|---|
| Mechanism of action | inactivates Na channels on nicotinic receptors |
| Dose | Intubating dose: 1mg/kg - can repeat dose, technically up to 500mg/day?! |
| Pharmacokinetics | Absorption Distribution Metabolism plasma cholinesterases Elimination |
| Time course of action | |
| Adverse effects | fasciculations increased IOP hyperkalaemia and there's also - apnoea - Anaphylaxis |
| Contraindications | Hyperkalaemia, severe burns, major trauma Myopathies, congenital myotonic disease (FHx or personal history) Personal or FHx malignant hyperthermia Low plasma cholinesterase activity e.g. liver disease |
mechanism of prolonged paralysis
- resisting cholinesterase activity