Type example of proton pump inhibitors

Uses:	Peptic and duodenal ulcers, H pylori eradication, GI bleed after endoscopy
Mechanism of action	Irreversible binding to sodium-potassium ATPase in gastric parietal cells. More effective than
Dose	20-80mg typically
Pharmacokinetics	Absorption PO, IV Distribution Metabolism P450 - liver. Duration of action 2-3 days due to covalent binding. t½ however is 1-2h. Elimination
Time course of action
Adverse effects	↑ risk gastrointestinal infections Hyponatraemia

deprescribing - BMJ advice

has the indication for PPI resolved?
mild-moderate oesophagitis s/s resolved
after 4-8 weeks treatment for GORD if symptoms controlled
after 2-12 weeks treatment for peptic ulcer disease, functional/empirically treated dyspepsia
stress ulcer prophylaxis in critical care - on leaving ICU
asymptomatic, uncomplicated H pylori infection on completing 2/52 course

Omeprazole