Dihydropyridine CCBs

Amlodipine

being our familiar friend

Nifedipine

Uses: Hypertension, Raynaud's
Mechanism of action blocks vascular L-type calcium channels
Net effect vasodilation of arterial resistance vessels
increased coronary perfusion
Dose
Pharmacokinetics Absorption
Distribution
Metabolism
Elimination t½ 2h
Time course of action t 1/2 4h
Adverse effects
Contraindications
flushing, constipation, peripheral oedema
acute angina, significant aortic stenosis, cardiogenic shock

Nimodipine

Uses: reduce vasospasm in SAH
Mechanism of action dihydropyridine calcium channel blocker - specific affinity for cerebral blood vessels
Net effect
Metabolism
Elimination
Time course of action
Adverse effects