Metronidazole
| Uses: | antibacterial; antiprotozoal; amoebic infections |
|---|---|
| Mechanism of action | DNA damage with free radicals |
| Dose | |
| Pharmacokinetics | Absorption PO, IV Distribution Metabolism Elimination renal + dialysed; excreted in breast milk |
| Adverse effects | GI upset, disulfiram-like reaction with alcohol (recommend avoid 48h after stopping) |
| Important drug interactions | ↑ effect of warfarin due to inhibition of P450 ↑ concentration of lithium |