Gentamicin
| Uses: | Gram negatives incl Pseudomonas, listerial meningitis with other abx, infective endocarditis with other abx, surgical prophylaxis... |
|---|---|
| Mechanism of action | Inhibits bacterial protein synthesis (misreading of mRNA message!) - acts on 30S subunit of ribosome |
| Dose | Slow IV infusion: 3-5 mg/kg TDS or 5-7 mg/kg OD Surgical prophylaxis: 1.5mg/kg |
| Pharmacokinetics | Absorption IM/IV Distribution Metabolism Elimination renal. |
| Time course of action | |
| Adverse effects | Dose-related oto/nephrotoxicity ↑ risk ototoxicity with loop diuretics GI upset ↑ effect of neuromuscular blockade? |
| Monitoring | .. |