Doxycycline
| Uses: | Chlamydia, Rickettsia, Brucella, MRCEM pathology/Microbiology/Mycoplasma pneumonia, H flu... |
|---|---|
| Mechanism of action | Interferes with bacterial protein synthesis by competing with tRNA for the A site of the ribosome and reversibly inhibiting its binding to the mRNA codons in the 30s subunit. (Rang and Dale) |
| Dose | 200mg loading, 100mg OD thereafter - for susceptible infections Chlamydia: 100mg BD |
| Pharmacokinetics | Absorption PO Distribution Metabolism Elimination |
| Time course of action | |
| Adverse effects | Teeth staining NB tetracycline contraindicated in children age <12 due to risk of tooth staining/dental hypoplasia Caution with Myasthenia gravis and lupus |
