Ciprofloxacin
As a type example of a quinolone.
| Uses: | UTI, Gonorrhea, and other susceptible infections |
|---|---|
| Mechanism of action | Inhibits DNA gyrase (aka topoisomerase I |
| Dose | Uncomplicated gonorrhea: PO 500mg one off UTI: 500mg BD 7 d |
| Pharmacokinetics | Absorption PO Distribution Metabolism liver Elimination |
| Time course of action | max concentration in |
| Adverse effects | Tendon |
| Important interactions | NSAIDs - lowers seizure threshold Warfarin - increases exposure to warfarin Clozapine - ↑ exposure to clozapine MTX - ↑ risk toxicity? |
CNS effects of quinolones
- due to competitive binding at GABA receptors (whyyyy)
- lowers seizure threshold → monitor closely with phenytoin