Chloramphenicol

Uses: Broad spectrum. Best known as topical for eyes, but available IV and PO for H influenzae infections
Mechanism of action inhibits bacterial protein synthesis by inhibiting transpeptidation - 50S subunit of ribosomes
Dose
Pharmacokinetics Absorption
Distribution
Metabolism
Elimination
Time course of action
Adverse effects Bone marrow suppression
'Grey baby' appearance
Aplastic anaemia - with a genetic predisposition
P450 inhibitor

#antibiotics