Heparin

Specifically referring to unfractionated heparin

Uses:
Mechanism of action Accelerates action of antithrombin III (ATIII), increasing inactivation of factors IIa (thrombin) & Xa
Dose 5000-10000 units
or continuous IV infusion
Pharmacokinetics Absorption IV or SC
Distribution
Metabolism liver.
Elimination renal
Time course of action t½ 40-60 min; dose dependent
Adverse effects HIT (5-10 days); hyperkalaemia (inhibition of aldosterone)
Thrombocytopaenia, hypersensitivity reactions, osteoporosis

Reversal/overdose treatment - protamine sulfate
Dose adjusted to APTT

#pharmacology #coagulation

differences between unfractionated heparin and LMWH
Enoxaparin

Rang and Dale
https://www.medicines.org.uk/emc/product/1681/smpc