Heparin

Specifically referring to unfractionated heparin

Uses:
Mechanism of action Accelerates action of antithrombin III (ATIII), increasing inactivation of factors IIa (thrombin) & Xa
Dose
Pharmacokinetics Absorption IV
Distribution
Metabolism
Elimination
Time course of action
Adverse effects HIT (5-10 days); hyperkalaemia (inhibition of aldosterone)
Thrombocytopaenia, hypersensitivity reactions, osteoporosis

Overdose treated with protamine sulfate
Dose adjusted to APTT

#incomplete

differences between unfractionated heparin and LMWH
Enoxaparin

Rang and Dale