Hypersensitivity reactions
| Type | Description | Mediators | Examples |
|---|---|---|---|
| Type 1 | Allergy (immediate) | IgE (via eosinophils, mast cells) | Anaphylaxis Atopy asthma |
| Type 2 | Cytotoxic / Antibody dependent | IgG IgM Complement MAC |
Autoimmune haemolytic anaemia Rheumatic fever Goodpastures (anti-GBM) syndrome Pernicious anaemia Thrombocytopenia Graves disease Myasthenia gravis |
| Type 3 | Immune complex mediated | IgG Complement Neutrophils |
SLE Rheumatoid arthritis External allergic alveolitis Post streptococcal glomerulonephritis |
| Type 4 | Delayed hypersensitivity reactions | T-cells | Contact Dermatitis Mantoux test Multiple Sclerosis Granulomatous inflammation Scabies Guillan-Barré syndrome |