Drug-related hyperthermias
the two main entities
Serotonin syndrome and Neuroleptic malignant syndrome
malignant hyperthermia
NMS and serotonin syndrome
see the deranged physiology link
BOTH are hot, wet (sialologue) and hypertonic
- No clonus in NMS
| NMS | Serotonin syndrome |
|---|---|
| Onset over days | Onset within hours |
| Normal pupils | Dilated pupils |
| Lead-pipe rigidity without clonus | Clonus |
| Dantrolene? Bromocriptine |
Benzodiazepines Cyproheptadine |