TRALI
| It's like ARDS. | |
|---|---|
| Etiology | 'non-cardiogenic pulmonary oedema and acute hypoxia occurring within six hours of a transfusion in the absence of other causes of acute lung injury or circulatory overload.' Often in response to platelet/plasma transfusion |
| Clinical presentation | Hypoxia, resp distress |
| Pathogenesis | Granulocyte activation in pulmonary vascular = ↑ capillary membrane permeability |
| Management | Treat as ARDS - A-E resuscitation +/- ICU involvement |