glomerulonephritis
| Autoimmune associations, membranous, minimal change, FSGS | |
|---|---|
| Etiology | Post-streptococcal glomerulonephritis: 1-2 weeks after throat infection or 6/52 after skin infection Associated with autoimmune hepatitis |
| Clinical presentation | Haematuria, oedema, hypertension (diastolic >80 or >90 if age>13), AKI |
| Pathogenesis | - Damage to glomerulus → compensatory ↑ BP - Damage to filtration mechanism → protein and blood in urine - Loss of filtration capacity → AKI |
| Diagnostic investigations | Quantify damage - Urine dip → urine protein-/albumin-creatinine ratio; U+E Underlying cause - ASOT, Complement (expect ↓ C3) |
| Management | depends on underlying cause Minimal change: steroids |