necrotising enterocolitis

Headline
Etiology Disproportionate inflammatory response in immature bowel to enteral feeding.
Site: terminal ileum, caecum, ascending colon.
Onset: most common in week 2-3 of life.
Epidemiology Risk factors: very low birth weight infants most at risk. Prematurity (↑ if <32/40), IUGR, hypoxia, polycythaemia, exchange transfusion
1-5% incidence in the NICU population!
Clinical presentation Think intra-abdominal septic picture.
abdo pain + distension, rectal bleeding, bilious vomiting.
All other nasty sequelae of sepsis: Disseminated intravascular coagulation, intestinal perforation, hepatic portal venous gas
Radiology: portal venous gas, pneumatosis intestinalis, dilated bowel loops, thumb printing
Pathogenesis
Diagnostic investigations
Management - Fluid resuscitation
- Broad spectrum antibiotics - for gut translocation, hence gram neg and anaerobic cover
- TPN
- Immunomodulation: steroids? probiotics?
- Surgical interventions: resection, drainage, anastomosis
Prevention Breast milk, gradual introduction of enteral feeding in preterm infants