routinely

at 28/40 for rhesus negative patients

after sensitising event

Anti-D should be given within 72h of sensitising event
To rhesus-negative women

Women who have heavy or repeated bleeding or where there is associated abdominal pain in the first trimester.
Women having a spontaneous miscarriage or threatened miscarriage or who suffer from intermittent bleeding after the first trimester.
Women having a therapeutic termination of pregnancy.
Women having an ectopic pregnancy.
Women who undergo intervention to remove products of conception.
Women who have potentially sensitising events at any stage of pregnancy

Gestation	Kleihauer test?	Min dose
<12/40 only for: - ectopic or molar pregnancies - therapeutic termination of pregnancy - heavy or repeated uterine bleeding - painful bleeding	no	250 IU
12-20/40	no	250 IU
>20/40	yes	500 IU

Administration of anti-D to rhesus-negative women is not required with

Women who are already sensitised
Women suffering a complete miscarriage before 12 weeks
Women who have PV bleeding in the first 12 weeks and continue to have a viable pregnancy