subarachnoid haemorrhage

the notorious "thunderclap"
Etiology 85% aneurysmal (van Gijn and Rinkel 2001), with highest risk of rebleed in first few days
Epidemiology F>M 1.6:1. Peak age: 50-55.
Risk factors: age, hypertension, smoking, ADPKD
Clinical presentation maximal onset within seconds to minutes
Pathogenesis
Diagnostic investigations CT within 6h - less useful after that
LP - xanthochromia
CT angiogram after 2/52
Ddx: reversible cerebral vasoconstriction syndrome - usually accompanied by trigger (Cittadini and Matharu 2009)
Management A/B: does this patient need I+V (airway protection)
C: Nimodipine - prevent vasospasm; BP control; Anticoagulant reversal if necessary
D: Neurosurgical referral for clipping/coiling, ICP management

Screening: only if >1 first-degree relative affected - only via specialty services to offer appropriate counselling

ottawa SAH rule: investigate further if any of the 6 rules are met

  1. neck pain/stiffness
  2. onset during exertion
  3. peak intensity immediately
  4. = 40 years old

  5. witnessed LOC
  6. limited neck flexion on examination

recent relevant research: SHED-CT

Relevant studies: SHED https://emj.bmj.com/content/41/12/719
http://www.ncbi.nlm.nih.gov/pubmed/11157554
Cittadini E, Matharu MS. Symptomatic trigeminal autonomic cephalalgias. Neurologist 2009;15:305-312.
https://www.bmj.com/content/389/bmj-2024-083247/infographic
https://www.nice.org.uk/guidance/NG228