DNA herpesvirus, causes proliferation of T cells = toxic to EBV-infected cells. Saliva spread + 4/5wk incubation. Associated with Ca stomach, ENT, lymphoma.

	Glandular fever
Etiology
Epidemiology	Peak age: 15-24 years
Public health considerations	incubation 4-6 weeks - contagious during incubation period no exclusion period
Clinical presentation	Sore throat, palatal petechiae, fever, malaise, bilateral posterior cervical lymphadenopathy, splenomegaly
Pathogenesis
Diagnostic investigations	Blood film: atypical lymphocytes; LFTs may be deranged ➥ Monospot test is diagnostic; age >12 - do in 2nd week of illness ➥ EBV-specific Abs: VCA-IgM present at s/s onset; VCA-IgG persists for life ➥ In pts with haemolytic anaemia, ↑ retics
Management	Complications: splenic rupture (advise avoid contact sports 8/52), Guillain-Barré, CNS inflam, CN lesions, hepatitis, myeloradiculitis, renal failure, myocarditis, aplastic anaemia - Management is otherwise supportive. - Abx can result in maculopapular + pruritic rash (adults>children)

counselling to avoid splenic rupture

no heavy lifting
no contact sports for 1st month of illness

#incomplete #virology