Pyrexia of Unknown origin

Why unknown origin? Means a disease process with non-specific, non-focal symptoms

etiology

infective

Non-specific symptoms, or attributable to other causes
Poor tissue penetration by abx, or non-bacterial infection treated like a bacterial infection

autoimmune/rheum

neoplastic process

  • Lymphomas

endocrine

others and rare disorders

  • VTE
  • familial Mediterranean fever

which investigation?

  • Chest imaging for all!