Malaria epidemiology
species
plasmodium falciparum
- P. falciparum is the most pathogenic and resistant to standard antimalarials
- can be rapidly fatal
- lacks a liver phase (hypnozooites)
incubation period
- 9 to 14 days for P falciparum
- 12 to 18 days for P. vivax and P. ovale.
- 18 to 40 days for P. malariae
generic life cycle
| Stage | Organ | |
|---|---|---|
| Sporozoites | Enter liver | |
| asexual replication | Schizont | Liver (hepatocytes) |
| optional - inactive stage | Hypnozoite | Liver (hepatocytes) |
| replication in bloodstream | (When schizonts mature) Merozoites | Bloodstream → RBCs |
| Schizogony in bloodstream | Trophozoites (→ schizont → merozoite) | Bloodstream → RBCs |
- P. ovale and vivax have hypnozoites that can persist in the liver for many years
related topics
Malaria curriculum
Malaria treatment, Malaria clinical presentation
why do I have so many pages for this