Hepatitis B post exposure prophylaxis
| HBV status of exposed person | HbSAg positive source | Significant exposure, source unk | Significant exposure, HbSAg -ve source | Non-significant exposure with continued risk | Non-significant exposure with no further risk |
|---|---|---|---|---|---|
| Unvaccinated | Accelerated hep B vaccine course HBIG with first dose |
Accelerated hep B vaccine course | Consider course of hep B vaccine | Start course of hep B vaccine | No hep B prophylaxis |
| Partially vaccinated | One dose of hep B vaccine and finish course | One dose of hep B vaccine and finish course | Complete course of hep B vaccine | Complete course of hep B vaccine | Complete course of hep B vaccine |
| Fully vaccinated with primary course | Hep B vaccine booster if last dose ≥1year ago | Consider hep B vaccine booster if last dose ≥1year ago | No hep B prophylaxis | No hep B prophylaxis | No hep B prophylaxis |
| Known non-responder to hep B vaccine | HBIG Hep B vaccine booster Second dose of HBIG at one month |
HBIG Consider hep B vaccine booster Second dose of HBIG at one month |
No HBIG Consider hep B vaccine booster |
No HBIG Consider hep B vaccine booster |
No hep B prophylaxis |