thanks to those 4 months on AAU Blue/Frailty... .

	Antibiotic-associated diarrhoea
Etiology	usually some disturbance of gut microbiome - clindamycin, fluoroquinolones most commonly implicated
Clinical presentation	Diarrhoea, fever, abdo pain. N+V is less common. How dehydrated is the patient?
Pathogenesis
Diagnostic investigations	Stool culture + toxin (tho may just indicate colonisation) CT (not necessary for diagnosis): pancolitis
Management	Initial management: as with Impending septic doom Stop unnecessary abx and antimotility drugs! Specific treatment: PO vancomycin Fidaxomicin Stool transplant Hold enteral nutrition if ileus or megacolon

lowest risk abx

tetracyclines
macrolides

severity (according to CKS)

Non-severe — white cell count lower than 15 x 109/L, a rise in serum creatinine of 50% or less above the person's baseline level, and a core body temperature of 38.5°C (or lower) at presentation.
Severe — defined by:
- One of the following features at presentation:
  - White cell count of 15 x 109/L or higher.
  - A rise in serum creatinine levels greater than 50% above baseline.
  - Core body temperature above 38.5°C.
Fulminant (previously known as life-threatening or severe-complicated) — defined by any of the following features attributed to CDI:
- Hypotension.
- Evidence of septic shock.
- Evidence of ileus, toxic megacolon or bowel perforation.
- Rapid deterioration in clinical condition.