Neisseria gonorrhoea
| Headline | |
|---|---|
| Etiology | Gram negative diplococcus. Incubation: 2–5 days |
| Epidemiology | - 50% women asymptomatic - 10% men asymptomatic |
| Clinical presentation | |
| Pathogenesis | Virulence factors - pili - mediate adherence to host cells - OPA proteins - promote entry of bacteria into cells - much variance in expression |
| Diagnostic investigations | First catch NAAT ➥ Vulvovaginal/urethral ± rectal swab ➥ Urethral microscopy: intracellular cocci |
| Management | BASHH: ceftriaxone 500mg IM or azithromycin 1g PO as single dose ➥ Contact notification: with symptomatic urethritis, 2/52 before s/s or last sexual partner ➥ else: 3/12 before dx ➥ Offer STI screen! ➥ facilitates HIV transmission |