Pyrexia of Unknown origin
Why unknown origin? Suggests disease process with non-specific, non-focal symptoms
etiology
infective
Is it actually undertreated/untreated infectoin?
- Poor tissue penetration by abx, or non-bacterial infection treated like a bacterial infection
- Abscess
- Infective endocarditis
- Malaria
- Discitis
Infction with elusive organisms?
autoimmune/rheum
neoplastic process
- Lymphomas
endocrine
others and rare disorders
- VTE
- familial Mediterranean fever
which investigation?
- Chest imaging for all!
- PRobably cross sectional imaging sooner or later
- TOE?
- blood cutlures for sure