Pyrexia of Unknown origin
Why unknown origin? Suggests disease process with non-specific, non-focal symptoms
etiology
infective
Is it actually undertreated/untreated infectoin?
- Poor tissue penetration by abx, or non-bacterial infection treated like a bacterial infection
- Abscess
- Infective endocarditis
- Discitis
Infection with elusive organisms?
autoimmune/rheum
neoplastic process
- Lymphomas
- Paraneoplastic syndromes
endocrine
others and rare disorders
- VTE
- familial Mediterranean fever
- In specific ICU settings: Central hyperthermia
which investigation?
- Chest imaging for all!
- Probably cross sectional imaging sooner or later
- TOE?
- blood cultures for sure