	TTP - this is worth waking up the on call haematologist.
Etiology	Autoimmune (40-70%), drug-related (e.g. clopidogrel), hereditary ADAMST13 mutations... see below
Clinical presentation	Fever, MAHA, purpuric rash, neuro symptoms, AKI Complications:
Pathogenesis	ADAMTS13 damage or inhibition → vWF not cleaved → microvascular thrombosis
Diagnostic investigations	Thrombocytopenia; ↑LDH, ↓ haptoglobins, clotting (normal). Exclude infection. Blood film: schistocytes
Management	Plasma exchange, FFP, rituximab

etiologies

Autoimmune haemolysis/Evans syndrome
Disseminated intravascular coagulation
Pregnancy‐associated e.g. HELLP (haemolysis, elevated liver enzymes and low platelets), eclampsia
Drugs eg quinine, simvastatin, interferon, Calcineurin inhibitors
Malignant hypertension
Infections, typically viral (cytomegalovirus, adenovirus, Herpes simplex virus) or severe bacterial (meningococcus, pneumococcus), fungal
Autoimmune disease (lupus nephritis, acute scleroderma)
Vasculitis
Haemolytic uraemic syndrome (diarrhoea positive/negative)
Malignancy
Catastrophic antiphospholipid syndrome

sources/links