non-Hodgkin lymphoma
| Headline | |
|---|---|
| Etiology | - malignancy arising in lymphoid arm of immune system - i.e. B cell, T cell or natural killer cells - strong association with viruses and other bacterial infections, e.g. EBV, HIV, Hepatitis C, Herpesvirus infections - HHV8, H pylori... - sporadic – c-myc gene translocation. Types: diffuse large B-cell, follicular most common. Associated infections: HTLV, H. pylori |
| Epidemiology | |
| Clinical presentation | Mediastinal mass |
| Pathogenesis | |
| Diagnostic investigations | FBC: anaemia/pancytopenia (some subtypes → lymphocytosis) Blood film: left shift (WBC precursor), nucleated RBCs Flow cytometry, biopsy |
| Management | Be a bit much to be comprehensive here but: B cell: RCHOP CNS lymphoma: methotrexate-based chemo (MTX + rituximab, vincristine etc.) Burkitt's: R-CODOX, R-EPOCH |