Megaloblastic anaemia
clinical presentation
"lemon tinge" = pallor and jaundice
glossitis, angular cheilitis
pathogenesis
B12 deficiency leads to abnormal/diminished DNA
- erythrocytes not maturing correctly
lab findings
FBC findings
- macrocytic anaemia
- ↑ indirect serum bilirubin, ↑ LDH
blood film
- hypersegmented neutrophils
bone marrow
- hypercellular BM
- giant metamyelocytes
- megaloblastic erythropoiesis