acute myeloid leukaemia
| AML, APML... | |
|---|---|
| Etiology | median age 65 |
| Epidemiology | |
| Clinical presentation | Signs of thrombocytopenia +/- extramedullary infiltration e.g. hepatosplenomegaly |
| Pathogenesis | |
| Investigations: | FBC: normochromic normocytic anaemia, thrombocytopenia, leukocytosis (5-20% of cases) AND neutropenia Bone marrow: hypercellular, blast cells, Auer rods Blood film: myeloid blasts, Auer rods DIC may occur in APML |
| Management: | prevention/management of Tumour lysis syndrome |
APML = acute promyelocytic leukaemia