Frontotemporal dementia
| Headline | |
|---|---|
| Etiology | |
| Epidemiology | Less common, but be suspicious if onset age<65 - 20% of early onset dementia. M=F. |
| Clinical presentation | • Behaviour: impulsivity, apathy, ↓ interpersonal skills, rituals/obsessionsm, ∆ eating behaviour (hyperorality) • Semantic: ↓ understanding of word meanings, concepts; difficulty with name retrieval • "empty" fluent speech = L temporal lobe • Progressive non-fluent: effortful speech; comprehension intact • Memory loss not usually predominant feature |
| Pathogenesis | Deposition of abnormal protein, often tau. Genetic component? with Parkinson’s Disease, linked to MAPT mutations on chromosome 17 |
| Diagnostic investigations | CT head: "knife-blade" atrophy Ddx: Vascular dementia |
| Management | Complications: |
| Prevention |