Hashimoto's thyroiditis
| Headline | |
|---|---|
| Etiology | Chronic lymphocytic thyroiditis = ~CD4+ T cell activation ⇒ B cell stimulation ⇒ destruction of follicular cells |
| Epidemiology | F>>M 20:1, age of onset 60-70 |
| Clinical presentation | see hypothyroidism |
| Pathogenesis | |
| Diagnostic investigations | Auto-antibodies: TPO, thyroglobulin Histo: ± oncocytic change |
| Management | Replace with levothyroxine ➥ ↑ clearance of Vit K-dependent clotting factors = ↑ warfarin requirements ➥ Titrate to TSH ➥➥ Recurrent thyroiditis: consider ablation (rare) |