Hypertensive emergency

  • Some define it as BP >180/110???
  • British and Irish Hypertension Society 2023: elevated BP, which when sustained over the next few hours may lead to progressive life-threatening end organ damage
  • End-organ damage makes it an emergency - without this, it is simply 'urgency'
  • has their own methods for lowering BP:
  • Aim ↓ 20-25% in first 2 hours

if treatment is truly indicated...

For hypertensive emergencies, the aim is to reduce Mean Arterial Pressure (MAP*) by up to 25% in the first hour of treatment

choice of agents

  • sodium nitroprusside
    • advantages: rapid on and offset, titratable
  • labetalol - alpha and beta blockade = vascular smooth muscle dilatation
    • advantages: no reflex tachycardia
    • predictable and titratable
  • nitrates - GTN. ↓ preload
    • advantages: coronary vasodilator
    • useful if patient is bradycardic tho
  • nicardipine
    • advantages: considered safe in pregnancy
    • disadvantages: -ve inotrope
  • hydralazine
    • disadvantages: reflex tachycardia; avoid in cerebral disease