	Headline
Etiology	following typically lymphoproliferative malignancy and chemo/radiotherapy or steroids - typically 12-72h post chemo
Epidemiology
Clinical presentation	GI upset, haematuria, fluid overload B: fluid overload? C: arrhythmia, shock D: weakness, tetany E: renal failure
Pathogenesis	Cell breakdown, releasing intracellular toxic contents... like Rhabdomyolysis?? - Purine nucleic acids in circulation → ↑ urate - Renal impairment: ↓ volume, tubular necrosis, precipitation of uric acid crystals, ↓ renal perfusion
Diagnostic investigations	Bloods: ↑ K, ↑ PO4, Hypocalcaemia, ↑ urate, renal failure, ↑ LDH, metab acidosis
Management	Treat each electrolyte derangement as you would normally +/- CRRT Urate: rasburicase, allopurinol
prevention	risk assessment for patients undergoing chemotherapy + pre-emptively avoiding nephrotoxics

associations

poorly differentiated lymphomas, e.g. Burkitt’s lymphoma and high-grade non-Hodgkin lymphoma
leukaemias, e.g. acute myeloid leukemia (AML), transformed chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL)
some fast-growing solid tumours such as hepatocellular carcinoma, hepatoblastoma, testicular cancer, small cell lung cancer, breast cancer and neuroblastoma.

sources/links